S-Monovette® cfDNA Exact

Excellent stabilization of liquid biopsy samples

In the blood, DNA is mainly found within the cells in the cell nucleus. In addition, however, it is also possible to find small amounts of fragmented DNA in the blood plasma, which is located outside the cells (cell-free DNA). This cell-free DNA (cfDNA for short) is usually a degradation residue of destroyed cells.

The analysis of cfDNA plays an increasing role in the early detection of transplant rejections and non-invasive prenatal tests, as well as the molecular characterization and therapy monitoring of cancers.

In order for cfDNA to be used for the analyses, a minimum concentration in the liquid biopsy sample is required. Without stabilization, the cells present in the blood sample begin to perish within a few hours and release genomic DNA (gDNA). As a result, the original cfDNA portion in the plasma is masked too strongly by released gDNA and analysis is no longer possible.

The problem is solved by the new S-Monovette® cfDNA Exact, which stabilizes the cfDNA at 4 °C to 37 °C for up to 14 days. The release of gDNA from nucleated cells is prevented over this period of time.

The S-Monovette® cfDNA Exact standardizes the pre-analysis of liquid biopsy samples and guarantees excellent sample quality as well as accurate results. 


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